Soutenances

Soutenance en 2005 « Synthèse et évaluation pharmacologique de composés indoliques et pyridopyraziniques à visée antitumorale » (Guillaume Le Baut, Pascal Marchand, Faculté de pharmacie de Nantes)

Synthesis and pharmacological evaluation of antitumor indole and pyridopyrazine compounds (http://www.theses.fr/2005NANT39VS)

Post-doc 2006-2008, Faculté de pharmacie de Nantes – Synthèse de pyrido[3,4-b]pyrazines et de 1,5-naphthyridines

Publications

Side chain modifications of (indol-3-yl)glyoxamides as antitumor agents, Journal of Enzyme Inhibition and Medicinal Chemistry,2008, 23 (5), 686-695

Synthesis and structure–activity relationships of N-aryl(indol-3-yl)glyoxamides as antitumor agents, Bioorganic & Medicinal Chemistry, 2009, 17, 6715–6727

Preparation of Novel 2,3,8-Trisubstituted Pyrido[3,4-b]pyrazines and Pyrido[2,3-b]pyrazines, Synthesis, 2011, 5, 794–806

A Convenient Synthesis of Novel 2,8-Disubstituted Pyrido[3,4-b]pyrazines Possessing Biological Activity, Synthesis, 2012, 44, 69–82

Synthesis and biological evaluation of 2,3-diarylimidazo[1,2-a]pyridines as antileishmanial agents, European Journal of Medicinal Chemistry, 2012, 58 543-556

Discovery of 7-Aryl-Substituted (1,5-Naphthyridin-4-yl)ureas as Aurora Kinase Inhibitors, ChemMedChem, 2014, 9, 217 – 232

Discovery of (7-aryl-1,5-naphthyridin-2-yl)ureas as dual inhibitors of ERK2 and Aurora B kinases with antiproliferative activity against cancer cells, Bioorganic & Medicinal Chemistry Letters, 2014, 24, 3748–3752

Efficient synthesis of novel disubstituted pyrido[3,4-b]pyrazines for the design of protein kinase inhibitors, Med. Chem. Commun., 2016, 7, 224-229